Mary Pickford started in the theater at age seven touring with her family in a number of theater companies. She was known as "Baby Gladys Smith". In 1907, she took her mother’s maiden name, Pickford, and joined the David Belasco troupe, appearing in the long-running The Warrens of Virginia. She began her film career in 1909 with the American Mutoscope & Biograph Company working with director D.W. Griffith. For a short time in 1911, to earn more money, she joined the IMP Film Co. under Carl Laemmle. She returned to Biograph in 1912 and in 1913 joined the Famous Players Film Company under Adolph Zukor. She then joined First National Exhibitor's Circuit in 1918. In 1919 she helped to establish United Artists.

Like most movie stars of the silent era, Pickford’s career was fading as talkies became more popular among audiences. In her late thirties, she was no longer able to play the children, teenage spitfires and feisty young women so adored by her fans, nor could she play the sleekly elegant heroines of early sound.

Mary Pickford retired from acting in 1933. She continued to produce films for others, including Sleep, My Love (1948) with Claudette Colbert and Love Happy (1949) with the Marx Brothers.

1933 Secrets - Mary Marlowe / Mary Carlton

1931 Kiki – Kiki

1926 Sparrows – Molly

1926 The Black Pirate – Princess Isobel in Final Embrace - Cameo Appearance (uncredited)

1925 Ben-Hur: A Tale of the Christ – Chariot Race Spectator (uncredited)

1925 Little Annie Rooney – Little Annie Rooney

1924 Dorothy Vernon of Haddon Hall – Dorothy Vernon

1923 Rosita – Rosita, a street singer

1922 Tess of the Storm Country – Tessibel 'Tess' Skinner

1921 Little Lord Fauntleroy – Cedric Errol / Widow Errol

1921 Through the Back Door – Jeanne

1921 The Love Light – Angela Carlotti

1920 Suds – Amanda Afflick

1920 Pollyanna – Pollyanna Whittier

1919 Heart o' the Hills – Mavis Hawn

1919 The Hoodlum – Amy Burke

1919 Daddy-Long-Legs – Judy Abbott

1919 Captain Kidd, Jr. – Mary MacTavish

1918 One Hundred Percent American (Short) – Mayme

1918 Johanna Enlists – Johanna Renssaller

1918 How Could You, Jean? – Jean Mackaye

1918 M'Liss – Melissa 'M'liss' Smith

1918 Amarilly of Clothes-Line Alley – Amarilly Jenkins

1918 Stella Maris – Miss Stella Maris / Unity Blake

1917 All-Star Production of Patriotic Episodes for the Second Liberty Loan

1917 The Little Princess – Sara Crewe

1917 Rebecca of Sunnybrook Farm – Rebecca Randall

1917 The Little American – Angela Moore

1917 A Romance of the Redwoods – Jenny Lawrence

1917 The Poor Little Rich Girl – Gwendolyn 'Gwen'

1917 The Pride of the Clan – Marget MacTavish

1916 Less Than the Dust – Radha

1916 The Eternal Grind – Louise

1916 Hulda from Holland – Hulda

1916 Poor Little Peppina – Peppina

1916 The Foundling – Molly O

1915 Broken Hearts

1915 Madame Butterfly – Cho-Cho-San

1915 A Girl of Yesterday – Jane Stuart

1915 Esmeralda (Short) – Esmeralda Rogers

1915 Rags – Rags /Alice McCloud

1915 Little Pal – 'Little Pal'

1915 The Dawn of a Tomorrow – Glad

1915 Fanchon, the Cricket – Fanchon, the cricket

1915 Love's Reflection (Short)

1915 Wifey's Fling (Short)

1915 Mistress Nell – Nell Gwyn

1914 Cinderella – Cinderella

1914 Behind the Scenes – Dolly Lane

1914 Such a Little Queen – Queen Anna Victoria

1914 The Eagle's Mate – Anemone Breckenridge

1914 Tess of the Storm Country – Tessibel Skinner

1914 A Good Little Devil – Juliet

1914 Hearts Adrift – Nina

1913 Caprice – Mercy Baxter

1913 In the Bishop's Carriage – Nance Olden

1913 Fate (Short)

1913 The Unwelcome Guest (Short) – Jessie - the Slavey

1912 Grannie

1912 The New York Hat (Short) – Miss Mollie Goodhue (the girl)

1912 The Informer (Short) – The Confederate Captain's Sweetheart

1912 My Baby (Short) – The Wife

1912 The One She Loved (Short) – The Wife

1912 A Feud in the Kentucky Hills (Short) – The Daughter

1912 So Near, Yet So Far (Short) – The Young Woman

1912 Friends (Short) – Dora - the Orphan

1912 A Pueblo Romance

1912 A Pueblo Legend (Short) – The Indian Girl

1912 With the Enemy's Help (Short) – Faro Kate

1912 The Inner Circle (Short) – The Rich Italian's Daughter

1912 A Child's Remorse (Short)

1912 The Narrow Road (Short) – Mrs. Jim Holcomb

1912 An Indian Summer (Short) – The Widow's Daughter

1912 The School Teacher and the Waif (Short) – Nora, the Waif

1912 Lena and the Geese (Short) – Lena

1912 Home Folks (Short) – The Young Woman

1912 A Beast at Bay (Short) – The Young Woman

1912 A Lodging for the Night (Short) – The Mexican Girl

1912 The Old Actor (Short) – The Old Actor's Daughter

1912 Won by a Fish (Short) – The Woman

1912 Just Like a Woman (Short) – The Young Woman

1912 The Female of the Species (Short) – The Miner's Wife's Sister

1912 Fate's Interception (Short) – The Mexican Girl

1912 Iola's Promise (Short) – Iola

1912 A Timely Repentance (Short) – Mrs. Nordell - Heroine of the Movie within the Movie, The Wife's Desertion

1912 A Siren of Impulse (Short)

1912 The Mender of Nets (Short) – The Net-Mender

1912 Honor Thy Father II (Short) – Mary Fuller

1911 How Mary Fixed It (Short) – Mary

1911 The Caddy's Dream (Short)

1911 Science (Short) – Mrs. Crawford

1911 A Dog's Tale

1911 The Daddy's Dream

1911 The Portrait I (Short) – Little Vera - the Model

1911 Little Red Riding Hood I (Short) – Little Red Riding Hood

1911 Love Heeds Not Showers (Short) – Mary

1911 The Courting of Mary (Short) – Mary

1911 From the Bottom of the Sea (Short) – Undetermined Role (unconfirmed)

1911 His Dress Shirt (Short) – Mrs. Kirby

1911 The Better Way (Short) – Lillian Garvey - Salvation Army Lass

1911 The Sentinel Asleep (Short)

1911 'Tween Two Loves (Short) – Grace

1911 By the House That Jack Built (Short) – Undetermined Leading Role

1911 The Toss of a Coin (Short) – Alice Barton - the Farmer's Daughter

1911 The Call of the Song (Short) – Amy Gordon

1911 The Skating Bug (Short)

1911 At a Quarter of Two (Short) – Mrs. Warren

1911 A Gasoline Engagement (Short) – Flora Powell

1911 For the Queen's Honor (Short) – Princess Gilda

1911 In the Sultan's Garden (Short) – Haidee

1911 Behind the Stockade (Short) – Lucy

1911 Back to the Soil (Short) – Sadie Allen

1911 The Lighthouse Keeper (Short) – Polly Berry - the Lighthouse Keeper's Daughter

1911 The Master and the Man (Short) – Elsie Graham

1911 For Her Brother's Sake I (Short) – Madge Spotwood

1911 The Fair Dentist (Short) – Edith Morton - The Fair Dentist

1911 The Temptress I (Short)

1911 Second Sight (Short) – Gertrude Edgar

1911 As a Boy Dreams (Short) – Mary - the Captain's Daughter

1911 The Stampede I (Short) – Nello - The Bandit's Daughter

1911 Sweet Memories (Short) – Polly Biblett

1911 In Old Madrid (Short)

1911 The Fisher-Maid (Short) Paula - the Fisher-maid

1911 The Message in the Bottle (Short)

1911 Conscience (Short)

1911 A Decree of Destiny (Short) – Mary

1911 A Manly Man (Short)

1911 Artful Kate (Short) – Artful Kate Stanley

1911 Pictureland (Short) – Rosita

1911 The Convert (Short) Agnes Boyd

1911 Her Darkest Hour (Short) – Ruth

1911 When the Cat's Away (Short) – Dorothy - the Wife

1911 The Mirror (Short) – Dorothy

1911 At the Duke's Command (Short) – One of the Ladies of the Court

1911 Three Sisters (Short) – Mary

1911 Maid or Man (Short) – Jimmie's Sister

1911 The Dream (Short)

1911 Their First Misunderstanding (Short) – Mae Darcy

1911 The Italian Barber (Short) – Alice

1911 When a Man Loves (Short) – Tessie

1910 Little Nell's Tobacco (Short)

1910 White Roses (Short) – Betty

1910 A Child's Stratagem (Short)

1910 A Plain Song (Short) – Edith

1910 The Song of the Wildwood Flute (Short) – Dove Eyes

1910 Sunshine Sue (Short)

1910 Simple Charity (Short) – Miss Wilkins (as Gladys Nicholson)

1910 Waiter No. 5 (Short) – The Chief of Police's Son's Fiancée

1910 The Masher (Short)

1910 A Lucky Toothache (Short) – Bessie

1910 That Chink at Golden Gulch (Short)

1910 A Gold Necklace (Short) – Mazie

1910 The Iconoclast (Short)

1910 Examination Day at School (Short)

1910 A Summer Tragedy (Short) (unconfirmed)

1910 Little Angels of Luck (Short) (unconfirmed)

1910 Muggsy Becomes a Hero (Short) – Mabel

1910 Wilful Peggy (Short) – Peggy

1910 The Sorrows of the Unfaithful (Short) – Mary

1910 When We Were in Our Teens (Short) – Mary

1910 The Usurer (Short) – Invalid Daughter

1910 An Arcadian Maid (Short) – Priscilla

1910 The Call to Arms (Short) – A Messenger

1910 Serious Sixteen (Short)

1910 A Flash of Light (Short)

1910 What the Daisy Said (Short) – Martha (uncredited)

1910 Muggsy's First Sweetheart (Short) – Mabel Brown

1910 A Child's Impulse (Short) – Grace

1910 Never Again I (Short) – The Girl

1910 May and December (Short) – May

1910 The Face at the Window (Short)

1910 A Victim of Jealousy (Short) – The Wife's Friend

1910 In the Season of Buds (Short) – Mabel

1910 Ramona (Short) – Ramona

1910 An Affair of Hearts (Short)

1910 Love Among the Roses (Short) – The Lacemaker

1910 The Unchanging Sea (Short) – The Daughter as an Adult

1910 The Kid (Short) (unconfirmed)

1910 A Romance of the Western Hills (Short) – Indian

1910 A Rich Revenge (Short) – Jennie

1910 The Two Brothers (Short) – Mexican

1910 As It Is in Life (Short) – George Forrester's Daughter, as an Adult

1910 The Smoker (Short) – George's Wife

1910 His Last Dollar (Short)

1910 The Twisted Trail (Short) – Molly Hendricks

1910 The Thread of Destiny (Short) – Myrtle

1910 The Newlyweds (Short) – Alice Vance

1910 The Englishman and the Girl (Short) – The Girl

1910 The Woman from Mellon's (Short) – Mary Petersby, the Daughter

1910 The Call (Short)

1910 All on Account of the Milk (Short) – The Young Woman

1909 The Heart of an Outlaw (Short) – The Outlaw's Daughter, as an Adult

1909 To Save Her Soul (Short) – Agnes Hailey

1909 The Test (Short) – Bessie

1909 The Trick That Failed (Short) – Nellie Burt

1909 The Mountaineer's Honor (Short) – Harum-Scarum, a Mountain Girl

1909 A Sweet Revenge (Short)

1909 A Midnight Adventure (Short) – Eleanor

1909 The Restoration (Short) – Alice Ashford

1909 The Light That Came (Short)

1909 What's Your Hurry? (Short) – Mary

1909 The Gibson Goddess (Short) – On Sidewalk

1909 Lines of White on a Sullen Sea (Short) – Second Couple

1909 In the Watches of the Night (Short) – At Brainard's

1909 His Lost Love (Short) – Mary

1909 The Little Teacher (Short) – The Little Teacher

1909 Pippa Passes; or, The Song of Conscience (Short) – Girl in crowd

1909 Wanted, a Child (Short)

1909 The Awakening (Short) – The Widow's Daughter

1909 In Old Kentucky (Short) – Homecoming Party

1909 The Broken Locket (Short) – Ruth King

1909 Getting Even (Short) – Miss Lucy

1909 The Children's Friend (Short)

1909 The Hessian Renegades (Short) – Messenger's Sister

1909 The Sealed Room (Short) – A Lady-in-Waiting

1909 The Little Darling (Short) – Little Darling

1909 The Seventh Day (Short) –The Maid

1909 Oh, Uncle! (Short) – Bessie

1909 The Indian Runner's Romance (Short) – Blue Cloud's Wife

1909 His Wife's Visitor (Short) – Bessie Wright

1909 They Would Elope (Short) – Bessie

1909 A Strange Meeting (Short)

1909 The Slave (Short) – A Young Girl at Court

1909 Sweet and Twenty (Short) – Alice

1909 The Renunciation (Short) – Kittie Ryan

1909 Tender Hearts (Short) – Nellie

1909 The Cardinal's Conspiracy (Short) – A Disguised Servant

1909 The Country Doctor (Short) – Poor Mother's Elder Daughter (uncredited)

1909 The Necklace (Short) – The Maid / In Pawnshop

1909 The Way of Man (Short) – Winnie, Mabel's Cousin

1909 The Peachbasket Hat (Short) – On Street / In Store

1909 The Mexican Sweethearts (Short) – The Señorita

1909 Her First Biscuits (Short) – Biscuit Victim

1909 The Faded Lilies (Short) – At Party

1909 The Son's Return (Short) – Mary Clark

1909 The Lonely Villa (Short) – One of the Cullison Children

1909 The Violin Maker of Cremona (Short) – Giannina, Taddeo's Daughter

1909 What Drink Did (Short)

1909 His Duty (Short) – One of the children on the street

1909 Two Memories (Short) – Marion's Sister

1909 The Drive for a Life (Short)

1909 The Deception (Short)

1909 The Fascinating Mrs. Francis (Short)

1909 Mrs. Jones Entertains (Short) (as Dorothy Nicholson)